Comparison of Clinicopathologic Features and Survival of Histopathologically Amelanotic and Pigmented Melanomas: A Population-Based Study
Identifieur interne : 003B11 ( Main/Exploration ); précédent : 003B10; suivant : 003B12Comparison of Clinicopathologic Features and Survival of Histopathologically Amelanotic and Pigmented Melanomas: A Population-Based Study
Auteurs : Nancy E. Thomas ; Anne Kricker ; Weston T. Waxweiler ; Patrick M. Dillon ; Klaus J. Busam ; Lynn From ; Pamela A. Groben ; Bruce K. Armstrong ; Hoda Anton-Culver ; Stephen B. Gruber ; Loraine D. Marrett ; Richard P. Gallagher ; Roberto Zanetti ; Stefano Rosso ; Terence Dwyer ; Alison Venn ; Peter A. Kanetsky ; Drs. Irene Orlow ; Susan Paine ; David W. Ollila ; Anne S. Reiner ; Li Luo ; Honglin Hao ; Jill S. Frank ; Colin B. Begg ; Marianne BerwickSource :
- JAMA dermatology [ 2168-6068 ] ; 2014.
Abstract
Previous studies have reported that histopathologically amelanotic melanoma is associated with poorer survival than pigmented melanoma; however, small numbers of amelanotic melanomas, selected populations, lack of centralized pathology review, or no adjustment for stage limit interpretation or generalization of results from prior studies.
To compare melanoma-specific survival between patients with histopathologically amelanotic and those with pigmented melanoma in a large international population-based study.
Survival analysis with median follow-up of 7.6 years.
The Genes, Environment, and Melanoma study enrolled incident cases of melanoma diagnosed in 1998-2003 from international population-based cancer registries.
A total of 2,995 patients with 3,486 invasive primary melanomas centrally scored for histologic pigmentation.
Clinicopathologic predictors and melanoma-specific survival of histologically amelanotic and pigmented melanoma were compared using generalized estimating equations and Cox regression models, respectively.
Eight percent of melanomas (275 of 3,467) were histopathologically
amelanotic. Female sex, nodular and unclassified or other histologic
subtypes, increased Breslow thickness, presence of mitoses, severe solar
elastosis, and lack of a co-existing nevus were independently associated
with amelanotic melanoma (each
At the population level, survival after diagnosis of amelanotic melanoma is poorer than after pigmented melanoma because of its more advanced stage at diagnosis. It is probable that amelanotic melanomas present at more advanced tumor stages because they are difficult to diagnose. The association of amelanotic melanoma with presence of mitoses independently of Breslow thickness and other clinicopathologic characteristics suggests that amelanotic melanomas might also grow faster than pigmented melanomas. New strategies for early diagnosis and investigation of the biology of amelanotic melanoma are warranted.
Url:
DOI: 10.1001/jamadermatol.2014.1348
PubMed: 25162299
PubMed Central: 4262611
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001E80
- to stream Pmc, to step Curation: 001D36
- to stream Pmc, to step Checkpoint: 001695
- to stream Ncbi, to step Merge: 001D46
- to stream Ncbi, to step Curation: 001D46
- to stream Ncbi, to step Checkpoint: 001D46
- to stream Main, to step Merge: 003B58
- to stream Main, to step Curation: 003B11
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of Clinicopathologic Features and Survival of
Histopathologically Amelanotic and Pigmented Melanomas: A Population-Based
Study</title><author><name sortKey="Thomas, Nancy E" sort="Thomas, Nancy E" uniqKey="Thomas N" first="Nancy E." last="Thomas">Nancy E. Thomas</name></author><author><name sortKey="Kricker, Anne" sort="Kricker, Anne" uniqKey="Kricker A" first="Anne" last="Kricker">Anne Kricker</name></author><author><name sortKey="Waxweiler, Weston T" sort="Waxweiler, Weston T" uniqKey="Waxweiler W" first="Weston T." last="Waxweiler">Weston T. Waxweiler</name></author><author><name sortKey="Dillon, Patrick M" sort="Dillon, Patrick M" uniqKey="Dillon P" first="Patrick M." last="Dillon">Patrick M. Dillon</name></author><author><name sortKey="Busam, Klaus J" sort="Busam, Klaus J" uniqKey="Busam K" first="Klaus J." last="Busam">Klaus J. Busam</name></author><author><name sortKey="From, Lynn" sort="From, Lynn" uniqKey="From L" first="Lynn" last="From">Lynn From</name></author><author><name sortKey="Groben, Pamela A" sort="Groben, Pamela A" uniqKey="Groben P" first="Pamela A." last="Groben">Pamela A. Groben</name></author><author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K." last="Armstrong">Bruce K. Armstrong</name></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name></author><author><name sortKey="Marrett, Loraine D" sort="Marrett, Loraine D" uniqKey="Marrett L" first="Loraine D." last="Marrett">Loraine D. Marrett</name></author><author><name sortKey="Gallagher, Richard P" sort="Gallagher, Richard P" uniqKey="Gallagher R" first="Richard P." last="Gallagher">Richard P. Gallagher</name></author><author><name sortKey="Zanetti, Roberto" sort="Zanetti, Roberto" uniqKey="Zanetti R" first="Roberto" last="Zanetti">Roberto Zanetti</name></author><author><name sortKey="Rosso, Stefano" sort="Rosso, Stefano" uniqKey="Rosso S" first="Stefano" last="Rosso">Stefano Rosso</name></author><author><name sortKey="Dwyer, Terence" sort="Dwyer, Terence" uniqKey="Dwyer T" first="Terence" last="Dwyer">Terence Dwyer</name></author><author><name sortKey="Venn, Alison" sort="Venn, Alison" uniqKey="Venn A" first="Alison" last="Venn">Alison Venn</name></author><author><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name></author><author><name sortKey="Orlow, Drs Irene" sort="Orlow, Drs Irene" uniqKey="Orlow D" first="Drs. Irene" last="Orlow">Drs. Irene Orlow</name></author><author><name sortKey="Paine, Susan" sort="Paine, Susan" uniqKey="Paine S" first="Susan" last="Paine">Susan Paine</name></author><author><name sortKey="Ollila, David W" sort="Ollila, David W" uniqKey="Ollila D" first="David W." last="Ollila">David W. Ollila</name></author><author><name sortKey="Reiner, Anne S" sort="Reiner, Anne S" uniqKey="Reiner A" first="Anne S." last="Reiner">Anne S. Reiner</name></author><author><name sortKey="Luo, Li" sort="Luo, Li" uniqKey="Luo L" first="Li" last="Luo">Li Luo</name></author><author><name sortKey="Hao, Honglin" sort="Hao, Honglin" uniqKey="Hao H" first="Honglin" last="Hao">Honglin Hao</name></author><author><name sortKey="Frank, Jill S" sort="Frank, Jill S" uniqKey="Frank J" first="Jill S." last="Frank">Jill S. Frank</name></author><author><name sortKey="Begg, Colin B" sort="Begg, Colin B" uniqKey="Begg C" first="Colin B." last="Begg">Colin B. Begg</name></author><author><name sortKey="Berwick, Marianne" sort="Berwick, Marianne" uniqKey="Berwick M" first="Marianne" last="Berwick">Marianne Berwick</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25162299</idno><idno type="pmc">4262611</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262611</idno><idno type="RBID">PMC:4262611</idno><idno type="doi">10.1001/jamadermatol.2014.1348</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001E80</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E80</idno><idno type="wicri:Area/Pmc/Curation">001D36</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001D36</idno><idno type="wicri:Area/Pmc/Checkpoint">001695</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001695</idno><idno type="wicri:Area/Ncbi/Merge">001D46</idno><idno type="wicri:Area/Ncbi/Curation">001D46</idno><idno type="wicri:Area/Ncbi/Checkpoint">001D46</idno><idno type="wicri:doubleKey">2168-6068:2014:Thomas N:comparison:of:clinicopathologic</idno><idno type="wicri:Area/Main/Merge">003B58</idno><idno type="wicri:Area/Main/Curation">003B11</idno><idno type="wicri:Area/Main/Exploration">003B11</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparison of Clinicopathologic Features and Survival of
Histopathologically Amelanotic and Pigmented Melanomas: A Population-Based
Study</title><author><name sortKey="Thomas, Nancy E" sort="Thomas, Nancy E" uniqKey="Thomas N" first="Nancy E." last="Thomas">Nancy E. Thomas</name></author><author><name sortKey="Kricker, Anne" sort="Kricker, Anne" uniqKey="Kricker A" first="Anne" last="Kricker">Anne Kricker</name></author><author><name sortKey="Waxweiler, Weston T" sort="Waxweiler, Weston T" uniqKey="Waxweiler W" first="Weston T." last="Waxweiler">Weston T. Waxweiler</name></author><author><name sortKey="Dillon, Patrick M" sort="Dillon, Patrick M" uniqKey="Dillon P" first="Patrick M." last="Dillon">Patrick M. Dillon</name></author><author><name sortKey="Busam, Klaus J" sort="Busam, Klaus J" uniqKey="Busam K" first="Klaus J." last="Busam">Klaus J. Busam</name></author><author><name sortKey="From, Lynn" sort="From, Lynn" uniqKey="From L" first="Lynn" last="From">Lynn From</name></author><author><name sortKey="Groben, Pamela A" sort="Groben, Pamela A" uniqKey="Groben P" first="Pamela A." last="Groben">Pamela A. Groben</name></author><author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K." last="Armstrong">Bruce K. Armstrong</name></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name></author><author><name sortKey="Marrett, Loraine D" sort="Marrett, Loraine D" uniqKey="Marrett L" first="Loraine D." last="Marrett">Loraine D. Marrett</name></author><author><name sortKey="Gallagher, Richard P" sort="Gallagher, Richard P" uniqKey="Gallagher R" first="Richard P." last="Gallagher">Richard P. Gallagher</name></author><author><name sortKey="Zanetti, Roberto" sort="Zanetti, Roberto" uniqKey="Zanetti R" first="Roberto" last="Zanetti">Roberto Zanetti</name></author><author><name sortKey="Rosso, Stefano" sort="Rosso, Stefano" uniqKey="Rosso S" first="Stefano" last="Rosso">Stefano Rosso</name></author><author><name sortKey="Dwyer, Terence" sort="Dwyer, Terence" uniqKey="Dwyer T" first="Terence" last="Dwyer">Terence Dwyer</name></author><author><name sortKey="Venn, Alison" sort="Venn, Alison" uniqKey="Venn A" first="Alison" last="Venn">Alison Venn</name></author><author><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name></author><author><name sortKey="Orlow, Drs Irene" sort="Orlow, Drs Irene" uniqKey="Orlow D" first="Drs. Irene" last="Orlow">Drs. Irene Orlow</name></author><author><name sortKey="Paine, Susan" sort="Paine, Susan" uniqKey="Paine S" first="Susan" last="Paine">Susan Paine</name></author><author><name sortKey="Ollila, David W" sort="Ollila, David W" uniqKey="Ollila D" first="David W." last="Ollila">David W. Ollila</name></author><author><name sortKey="Reiner, Anne S" sort="Reiner, Anne S" uniqKey="Reiner A" first="Anne S." last="Reiner">Anne S. Reiner</name></author><author><name sortKey="Luo, Li" sort="Luo, Li" uniqKey="Luo L" first="Li" last="Luo">Li Luo</name></author><author><name sortKey="Hao, Honglin" sort="Hao, Honglin" uniqKey="Hao H" first="Honglin" last="Hao">Honglin Hao</name></author><author><name sortKey="Frank, Jill S" sort="Frank, Jill S" uniqKey="Frank J" first="Jill S." last="Frank">Jill S. Frank</name></author><author><name sortKey="Begg, Colin B" sort="Begg, Colin B" uniqKey="Begg C" first="Colin B." last="Begg">Colin B. Begg</name></author><author><name sortKey="Berwick, Marianne" sort="Berwick, Marianne" uniqKey="Berwick M" first="Marianne" last="Berwick">Marianne Berwick</name></author></analytic><series><title level="j">JAMA dermatology</title><idno type="ISSN">2168-6068</idno><idno type="eISSN">2168-6084</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Importance</title><p id="P1">Previous studies have reported that histopathologically amelanotic
melanoma is associated with poorer survival than pigmented melanoma;
however, small numbers of amelanotic melanomas, selected populations, lack
of centralized pathology review, or no adjustment for stage limit
interpretation or generalization of results from prior studies.</p></sec><sec id="S2"><title>Objective</title><p id="P2">To compare melanoma-specific survival between patients with
histopathologically amelanotic and those with pigmented melanoma in a large
international population-based study.</p></sec><sec id="S3"><title>Design</title><p id="P3">Survival analysis with median follow-up of 7.6 years.</p></sec><sec id="S4"><title>Setting</title><p id="P4">The Genes, Environment, and Melanoma study enrolled incident cases of
melanoma diagnosed in 1998-2003 from international population-based cancer
registries.</p></sec><sec id="S5"><title>Participants</title><p id="P5">A total of 2,995 patients with 3,486 invasive primary melanomas
centrally scored for histologic pigmentation.</p></sec><sec id="S6"><title>Main Outcomes and Measurements</title><p id="P6">Clinicopathologic predictors and melanoma-specific survival of
histologically amelanotic and pigmented melanoma were compared using
generalized estimating equations and Cox regression models,
respectively.</p></sec><sec id="S7"><title>Results</title><p id="P7">Eight percent of melanomas (275 of 3,467) were histopathologically
amelanotic. Female sex, nodular and unclassified or other histologic
subtypes, increased Breslow thickness, presence of mitoses, severe solar
elastosis, and lack of a co-existing nevus were independently associated
with amelanotic melanoma (each <italic>P</italic> < .05). Amelanotic
melanoma was generally of a higher American Joint Committee on Cancer (AJCC)
tumor stage at diagnosis (<italic>P</italic> for trend <.001) than
pigmented melanoma. Hazard of death from melanoma was higher for amelanotic
than pigmented melanoma [hazard ratio (HR), 2.0; 95%
confidence interval (CI), 1.4-3.0; <italic>P</italic><
.001], adjusted for age, sex anatomic site, and study design
variables; but survival did not differ once AJCC tumor stage was also taken
into account, (HR, 0.8; 95% CI, 0.5-1.2; <italic>P</italic>= .36).</p></sec><sec id="S8"><title>Conclusions and Relevance</title><p id="P8">At the population level, survival after diagnosis of amelanotic
melanoma is poorer than after pigmented melanoma because of its more
advanced stage at diagnosis. It is probable that amelanotic melanomas
present at more advanced tumor stages because they are difficult to
diagnose. The association of amelanotic melanoma with presence of mitoses
independently of Breslow thickness and other clinicopathologic
characteristics suggests that amelanotic melanomas might also grow faster
than pigmented melanomas. New strategies for early diagnosis and
investigation of the biology of amelanotic melanoma are warranted.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K." last="Armstrong">Bruce K. Armstrong</name><name sortKey="Begg, Colin B" sort="Begg, Colin B" uniqKey="Begg C" first="Colin B." last="Begg">Colin B. Begg</name><name sortKey="Berwick, Marianne" sort="Berwick, Marianne" uniqKey="Berwick M" first="Marianne" last="Berwick">Marianne Berwick</name><name sortKey="Busam, Klaus J" sort="Busam, Klaus J" uniqKey="Busam K" first="Klaus J." last="Busam">Klaus J. Busam</name><name sortKey="Dillon, Patrick M" sort="Dillon, Patrick M" uniqKey="Dillon P" first="Patrick M." last="Dillon">Patrick M. Dillon</name><name sortKey="Dwyer, Terence" sort="Dwyer, Terence" uniqKey="Dwyer T" first="Terence" last="Dwyer">Terence Dwyer</name><name sortKey="Frank, Jill S" sort="Frank, Jill S" uniqKey="Frank J" first="Jill S." last="Frank">Jill S. Frank</name><name sortKey="From, Lynn" sort="From, Lynn" uniqKey="From L" first="Lynn" last="From">Lynn From</name><name sortKey="Gallagher, Richard P" sort="Gallagher, Richard P" uniqKey="Gallagher R" first="Richard P." last="Gallagher">Richard P. Gallagher</name><name sortKey="Groben, Pamela A" sort="Groben, Pamela A" uniqKey="Groben P" first="Pamela A." last="Groben">Pamela A. Groben</name><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><name sortKey="Hao, Honglin" sort="Hao, Honglin" uniqKey="Hao H" first="Honglin" last="Hao">Honglin Hao</name><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name><name sortKey="Kricker, Anne" sort="Kricker, Anne" uniqKey="Kricker A" first="Anne" last="Kricker">Anne Kricker</name><name sortKey="Luo, Li" sort="Luo, Li" uniqKey="Luo L" first="Li" last="Luo">Li Luo</name><name sortKey="Marrett, Loraine D" sort="Marrett, Loraine D" uniqKey="Marrett L" first="Loraine D." last="Marrett">Loraine D. Marrett</name><name sortKey="Ollila, David W" sort="Ollila, David W" uniqKey="Ollila D" first="David W." last="Ollila">David W. Ollila</name><name sortKey="Orlow, Drs Irene" sort="Orlow, Drs Irene" uniqKey="Orlow D" first="Drs. Irene" last="Orlow">Drs. Irene Orlow</name><name sortKey="Paine, Susan" sort="Paine, Susan" uniqKey="Paine S" first="Susan" last="Paine">Susan Paine</name><name sortKey="Reiner, Anne S" sort="Reiner, Anne S" uniqKey="Reiner A" first="Anne S." last="Reiner">Anne S. Reiner</name><name sortKey="Rosso, Stefano" sort="Rosso, Stefano" uniqKey="Rosso S" first="Stefano" last="Rosso">Stefano Rosso</name><name sortKey="Thomas, Nancy E" sort="Thomas, Nancy E" uniqKey="Thomas N" first="Nancy E." last="Thomas">Nancy E. Thomas</name><name sortKey="Venn, Alison" sort="Venn, Alison" uniqKey="Venn A" first="Alison" last="Venn">Alison Venn</name><name sortKey="Waxweiler, Weston T" sort="Waxweiler, Weston T" uniqKey="Waxweiler W" first="Weston T." last="Waxweiler">Weston T. Waxweiler</name><name sortKey="Zanetti, Roberto" sort="Zanetti, Roberto" uniqKey="Zanetti R" first="Roberto" last="Zanetti">Roberto Zanetti</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003B11 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003B11 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4262611
|texte= Comparison of Clinicopathologic Features and Survival of
Histopathologically Amelanotic and Pigmented Melanomas: A Population-Based
Study
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25162299" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |